background: receptor for advanced glycation end products (rage) plays a causative role in diabetes. garlic (allium sativum) belongs to compounds with anti-glycation activity that can be considered as probable therapeutic approaches in delaying or preventing the onset of diabetes complications. the aim of this study was to evaluate the influence of garlic on the rage expression and proinflammato...

Introduction: Following a traumatic brain injury (TBI), the excessive release of proinflammatory cytokines is major cause of cerebral edema that can cause permanent neuronal loss. This study examined the changes in brain concentrations of proinflammatory cytokines IL-1, IL-6, TNF-α and TGF- after different doses of estrogen or progesterone treatment in brain-injured rats at 6 and 24 h post...

extra-cellular levels (serum) of heat shock protein 70 is influenced by various stressors such as exercise and it has been shown that this protein affects the proinflammatory cytokines in human and animal samples. the aim of this study was to investigate the effect of endurance training on serum levels of proinflammatory cytokines (tnf-?, il-1?, il-6 and hsp70) in trained and untrained rats. fo...

il-1β and il-17a are two cytokines with strong proinflammatory activities and are now known to be involved in a number of chronic inflammatory disorders. high-mobility group box 1 (hmgb1) is a nuclear protein regulating the expression of these proinflammatory cytokines. the nlrp3 inflammasome promotes the maturation of the il-1β and its activation has been shown as a critical mechanism in the p...

one of the most important problems in neuroscience researches is the understanding what is the communication between the immune system and central nervous system. proinflammatory factors play an important role in this communication. the dysregulation of proinflammatory factors such as cytokines and chemokines is a central feature in the development of neuroinflammation.one of the important  cyt...

One of the most important problems in neuroscience researches is the understanding what is the communication between the immune system and central nervous system. Proinflammatory factors play an important role in this communication. The dysregulation of proinflammatory factors such as cytokines and chemokines is a central feature in the development of neuroinflammation.one of the important&nbsp...